Please cite the following reference:

Tuncbag N, Gursoy A, Keskin O. Identification of computational hotspots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy. Bioinformatics. 2009 Jun 15;25(12):1513-20. [Link to article]

Tuncbag N, Keksin O., Gursoy A., Hotpoint: hot spot prediction server for protein interfaces. Nucleic Acids Research, 2010, Vol. 38, Web Server issue

HotPoint Webserver
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